East Sussex Fire and Rescue Service was called out to a property in Holmesdale Gardens, Hastings yesterday (Tuesday 2 December).
Crews from Bohemia Road and The Ridge in Hastings, along with firefighters from Bexhill were called out at 16:15 to reports of a fire alarm sounding.
Firefighters using breathing apparatus and a hose real rescued one person who was taken to hospital suffering from smoke inhalation.
Later, a further casualty was to hospital as a precaution suffering from possible smoke inhalation.
An investigation is underway.